De niet-invasieve prenatale test (NIPT) die al langer gebruikt wordt om bij een foetus chromosoomafwijkingen zoals het syndroom van Down vast te stellen, geeft ook uitsluitsel over het geslacht van de baby. Als je dit wil, tenminste. Maar, de geslachtsbepaling was tot voor kort niet mogelijk bij tweelingzwangerschappen, daar kon je immer enkel te weten komen of je minstens één jongen zou verwachten, of 2 meisjes. Maar onderzoekers van het Centrum Menselijke Erfelijkheid (CME) van de KU Leuven hebben daar nu verandering in gebracht.
De NIPT is een prenataal bloedonderzoek dat afwijkingen in de chromosomen van de foetus opspoort. De test kan eenvoudig worden uitgevoerd via een bloedafname bij de zwangere vrouw vanaf de twaalfde week. Het bloed van de moeder bevat immers ook kleine stukjes DNA van de baby.
Uit dat erfelijk materiaal van de foetus is ook af te leiden of het om een jongen of een meisje gaat: als er sprake is van een Y-chromosoom, gaat het om een jongetje. In België is de NIPT bijna gratis en zowat negentig procent van de zwangere vrouwen laat zich testen: wie wil, kan dus eenvoudig het geslacht van de ongeboren baby te weten komen. In Nederland test men bij de NIPT test dan weer niet het geslacht.
Hoeveel jongetjes?
Maar toekomstige ouders van tweelingen vielen tot nu toe deels uit de boot: bij een meisjestweeling was er geen probleem. Maar als de NIPT het Y-chromosoom detecteerde, was niet mogelijk uit te maken of het dan om één jongen en een zusje dan wel om twee jongetjes ging. “Het probleem was om de hoeveelheid aan Y-chromosoom te bepalen”, vertelt professor Joris Vermeesch. “Dat hebben we opgelost door te berekenen hoe groot het aandeel Y-chromosoom is in het foetaal DNA. Zo kunnen we accuraat voorspellen of het om één jongen of twee jongetjes gaat.”
“In België krijgt ongeveer één op de tachtig zwangere vrouwen een tweeling. Er is dus meer vraag naar de geslachtsbepaling en met deze verbeterde NIPT kunnen we ook die ouders helpen.”
Het aantal tweelingzwangerschappen zit in stijgende lijn, vooral door vruchtbaarheidsbehandelingen zoals in-vitrofertilisatie, vervolgt Vermeesch. “In België krijgt ongeveer één op de tachtig zwangere vrouwen een tweeling. Er is dus meer vraag naar de geslachtsbepaling en met deze verbeterde NIPT kunnen we ook die ouders helpen. In zeldzame gevallen heeft de test ook nut vanuit medisch standpunt. Sommige genetische aandoeningen komen immers enkel bij jongens voor. Maar gelukkig is de bepaling van het geslacht voor het gros van de ouders gewoon een leuk en handig weetje.”
Bron: KU Leuven
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